Host determinants of enterovirus neuropathogenesis
Abstract/Contents
- Abstract
- Enteroviruses (EVs) comprise a large genus of positive-sense single-stranded RNA viruses and are among the most common human infectious agents. EVs cause a wide range of diseases and recent outbreaks of several emerging EVs have been associated with severe neuropathogenesis highlighting their ongoing threat to public health. Apart from a vaccine against PV and two vaccines against EV-A71 in China, there are currently no approved antivirals or therapeutics to treat enterovirus infections. Thus, there is a pressing need to develop novel strategies for combating these medically important pathogens. Host-directed therapy (HDT) is an emerging strategy in the field of antivirals that aims to control viral infections by interfering with host cellular pathways. Evaluation of host targets for use in HDT is dependent on a comprehensive understanding of how a pathogen causes disease. In recent years, our understanding of how EVs co-opt cellular functions and cause disease has greatly accelerated with the advent of unbiased genetic and proteomic technologies and the use of human organoids to more accurately represent human viral infections. This thesis presents examples of applying genome-scale genetic screens to identify host proteins hijacked by enteroviruses to promote their replication and the use of human spinal cord organoids to better understand the mechanisms by which enteroviruses cause disease.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Peters, Christine Elise |
|---|---|
| Degree supervisor | Carette, Jan |
| Thesis advisor | Carette, Jan |
| Thesis advisor | Gozani, Or |
| Thesis advisor | Kirkegaard, Karla |
| Thesis advisor | Monack, Denise |
| Degree committee member | Gozani, Or |
| Degree committee member | Kirkegaard, Karla |
| Degree committee member | Monack, Denise |
| Associated with | Stanford University, School of Medicine |
| Associated with | Stanford University, Department of Microbiology and Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Christine Peters. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/zp541bt0939 |
Access conditions
- Copyright
- © 2023 by Christine Elise Peters
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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