Arendt 2023 BDNF

Name: Arendt 2023 BDNF
License: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

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Abstract/Contents

Abstract: Homeostatic synaptic plasticity is a non-Hebbian synaptic mechanism that adjusts synaptic strength to maintain network stability while achieving optimal information processing. Among the molecular mediators shown to regulate this form of plasticity, synaptic signaling through retinoic acid (RA) and its receptor, RARα, has been shown to be critically involved in the homeostatic adjustment of synaptic transmission in both hippocampus and sensory cortices. In this study, we explore the molecular mechanism through which postsynaptic RA and RARα regulates presynaptic neurotransmitter release during prolonged synaptic inactivity at mouse glutamatertic synapses. We show that RARα binds to a subset of dendritically sorted brain-derived neurotrophic factor (Bdnf) mRNA splice isoforms and represses their translation. The RA-mediated translational de-repression of postsynaptic BDNF results in the retrograde activation of presynaptic Tropomyosin receptor kinase B (TrkB) receptors, facilitating presynaptic homeostatic compensation through enhanced presynaptic release. Together, our study illustrates a RA-mediated retrograde synaptic signaling pathway through which postsynaptic protein synthesis during synaptic inactivity drives compensatory changes at the presynaptic site.

Author	Chen, Lu
Author	Arendt, Kristin

Subject	homeostatic synaptic plasticity
Genre	Data
Genre	Unedited recording
Genre	Data sets
Genre	Dataset

DOI	https://doi.org/10.25740/zk891by2827
Location	https://purl.stanford.edu/zk891by2827

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License: This work is licensed under a Creative Commons Attribution Non Commercial No Derivatives 4.0 International license (CC BY-NC-ND).

Preferred citation: Chen, L. and Arendt, K. (2023). Arendt 2023 BDNF. Stanford Digital Repository. Available at https://purl.stanford.edu/zk891by2827. https://doi.org/10.25740/zk891by2827.

Research from the Lu Chen Lab at Stanford

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