Examining the role of microglia in niemann-pick type C
Abstract/Contents
- Abstract
- Neurodegenerative diseases are ultimately fatal, complex, age-related diseases of the central nervous system, for which there are no reliable disease-modifying therapies. Multiple parallel lines of study have identified microglia, the immune effectors of the brain, as potential regulators in many neurodegenerative diseases. While the majority of neurodegenerative diseases are restricted to the aging population, genetic defects can illicit similar diseases in children, as is the case for many lysosomal storage diseases. Niemann-Pick Type C (NP-C) is a rare lysosomal storage disease characterized by progressive degeneration of cerebellar Purkinje neurons in childhood and early adolescence. Microglia in NP-C undergo many characteristic neurodegenerative changes including massive lysosomal accumulation and morphological disturbances. Despite this, there is limited research on NP-C microglia and their function in disease progression. In this thesis, we deeply dissect the function of microglia in NP-C. Utilizing RNA-seq, we define a transcriptional signature of microglia over the course of disease progression. We also examine the functional impact of microglia in NP-C. Transplantation of microglia into a naive brain is able to incite a reactive brain environment, a novel finding that shows that microglia actively alter their brain environment and are not latent bystanders
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Bonanno, Liana Nicole |
|---|---|
| Degree supervisor | Wyss-Coray, Anton |
| Thesis advisor | Wyss-Coray, Anton |
| Thesis advisor | Andreasson, Katrin |
| Thesis advisor | Monje-Deisseroth, Michelle |
| Thesis advisor | Wernig, Marius |
| Degree committee member | Andreasson, Katrin |
| Degree committee member | Monje-Deisseroth, Michelle |
| Degree committee member | Wernig, Marius |
| Associated with | Stanford University, Neurosciences Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Liana Nicole Bonanno |
|---|---|
| Note | Submitted to the Neurosciences Program |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Liana Nicole Bonanno
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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