Rapid adaptation in complex demographic scenarios

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Abstract/Contents

Abstract: This thesis explores the population genetics of rapid adaptation in demographically complex scenarios, extending analyses that were previously developed modeling populations of constant size. The first chapter extends the understanding of soft selective sweeps—adaptive events where more than one adaptive allele spreads through a population while selection is acting on a common trait—in the Wright-Fisher model of evolution to populations that fluctuate arbitrarily but predictably through time. The second chapter investigates soft selective sweeps in the context of evolutionary rescue, an phenomenon where a population destined for extinction is 'rescued' by the appearance and spread of an adaptive mutation. The third chapter reviews a specific case of rapid adaptation, the evolution of drug resistance, and the population genetic insights that have been gained and applied to the study of drug resistance.

Type of resource	text
Form	electronic; electronic resource; remote
Extent	1 online resource.
Publication date	2016
Issuance	monographic
Language	English

Associated with	Wilson, Benjamin A
Associated with	Stanford University, Department of Biology.
Primary advisor	Petrov, Dmitri Alex, 1969-
Thesis advisor	Petrov, Dmitri Alex, 1969-
Thesis advisor	Feldman, Marcus W
Thesis advisor	Fisher, Daniel
Advisor	Feldman, Marcus W
Advisor	Fisher, Daniel

Genre	Theses

Statement of responsibility	Benjamin A. Wilson.
Note	Submitted to the Department of Biology.
Thesis	Thesis (Ph.D.)--Stanford University, 2016.
Location	electronic resource

License: This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

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