The role of hyaluronic acid in regulating inflammation and the immune response
Abstract/Contents
- Abstract
- Hyaluronan (HA) is a disaccharide polymer consisting of glucuronic acid and N-acetyl glucosamine that dominates the extracellular space in the eukaryotic body. As part of the pericellular matrix (PCM), HA is extruded outward from the cell membrane in the mesh of proteins and sugars that make up the glycocalyx. This thick coat, consisting predominantly of HA, dominates the interface between a cell and its environment. HA plays an important role in cell communication within the extracellular space as well as tissue structure. In this thesis I will discuss the biological role of HA in chronic and acute disease. I focus on how dysregulation of HA production potentiates pathophysiology of three different inflammatory states: chronic asthma, type II diabetes, and solid organ transplantation. Moreover, I present investigations into 4-MU treatment to protect against inflammatory pathologies. Lastly, I present investigations looking at developing new interventions that can add to our repertoire of HA targeting therapies.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Marshall, Payton Lachlan |
|---|---|
| Degree supervisor | Bollyky, Paul |
| Thesis advisor | Bollyky, Paul |
| Thesis advisor | Engleman, Edgar G |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Maltzman, Jonathan |
| Thesis advisor | Meyer, Everett |
| Degree committee member | Engleman, Edgar G |
| Degree committee member | Heilshorn, Sarah |
| Degree committee member | Maltzman, Jonathan |
| Degree committee member | Meyer, Everett |
| Associated with | Stanford University, Department of Microbiology and Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Payton Lachlan Marshall. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/zf890cn3108 |
Access conditions
- Copyright
- © 2022 by Payton Lachlan Marshall
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