Beamlet-based treatment plan optimization in external beam radiation therapy
Abstract/Contents
- Abstract
- External beam radiation therapy is one of the most widely used therapeutic methods for treating patients. In this modality, prior to the actual treatment, machine delivery parameters are optimized based on a patient model derived from the pre-treatment CT images. The goal of treatment planning is to maximize the dose to the planning target volume (PTV), while sparing the critical organs. A number of treatment techniques have been developed to meet the clinical demands. In reality, however, these techniques suffer from a series of problems and the performance of currently available plan optimization and dose delivery techniques is sub-optimal - the treatment plans out of the optimization algorithms are often not clinically sensible. Hence, considerable effort may be required to plan a patient's treatment, seriously hindering the optimal and efficient use of the radiation therapy. This thesis presents efficient and effective fluence-map optimizing techniques to demonstrate the improvement in either plan quality or delivery efficiency in static field and (continuous) rotational arc treatment schemes. To attain the objective above, new mathematical models and beam configurations are employed in the center of the treatment planning and its optimizing process. Of note, the demonstrations of our proposed methods or strategies proceed in two directions: (1) improving the delivery efficiency without damaging the plan quality, and (2) enhancing the plan quality, while maintaining the similar delivery efficiency of the existing methods.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2014 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Kim, Ho-jin |
|---|---|
| Associated with | Stanford University, Department of Electrical Engineering. |
| Primary advisor | Xing, Lei |
| Thesis advisor | Xing, Lei |
| Thesis advisor | Candès, Emmanuel J. (Emmanuel Jean) |
| Thesis advisor | Pauly, John (John M.) |
| Advisor | Candès, Emmanuel J. (Emmanuel Jean) |
| Advisor | Pauly, John (John M.) |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Ho Jin Kim. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Ho Jin Kim
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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