Interrogation of viscoelastic protein layers at bubble interfaces
Abstract/Contents
- Abstract
- From a cup of creamed coffee to the salty spray of seawater, fluid-fluid interfaces exist everywhere in our lives. Simple fluid-fluid interfaces can be described by a scalar surface tension, but adherence of amphiphilic species such as small molecule surfactants, particles, and macromolecules, and the consequent formation of interfacial microstructures, results in the formation of a complex interface that is inadequately described by a simple surface tension. The scope of the thesis will wholly focus on complex air-aqueous solution interfaces, the presence of which can be undesirable, for example, in the form of isolated bubbles entrained in pharmaceutical processing flows, or desirable, as the foams for beverages and consumer products. Furthermore, the focus is on proteins at the air-aqueous solution interface which form a viscoelastic protein layer. The first project examines the aggregation of a proprietary monoclonal (mAb) molecule under interfacial deformations by investigating the mechanical response of mAb-adsorbed interfaces to dilatational strains and by characterizing particles ejected from dilatationally-compressed surfaces with spectroscopic and microscopic techniques. The project also introduces the interfacial dilatational rheometer that underpins much of the work and demonstrates its capabilities in studying the stability of product formulations. The second part of the thesis examines the influence of rheological surface elasticity on thin film entrainment within foams for bovine serum albumin (BSA) protein-adsorbed interfaces. The results of the latter study could be beneficial for industries interested in developing a framework for predicting bulk foam characteristics, such as liquid foam density, from interfacial and bulk liquid properties.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lin, Gigi L |
|---|---|
| Associated with | Stanford University, Department of Chemical Engineering. |
| Primary advisor | Fuller, Gerald G |
| Thesis advisor | Fuller, Gerald G |
| Thesis advisor | Cegelski, Lynette |
| Thesis advisor | Dunn, Alexander Robert |
| Advisor | Cegelski, Lynette |
| Advisor | Dunn, Alexander Robert |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Gigi L. Lin. |
|---|---|
| Note | Submitted to the Department of Chemical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Gigi Lee Lin
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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