A multimodal understanding of allergic disease
Abstract/Contents
- Abstract
- Allergic diseases such as allergic rhinitis, food allergies, and allergic asthma are characterized by an inappropriate immune response towards otherwise harmless environmental substances. Food allergies are a particularly extreme form of allergic disease as exposure to minute amounts of an allergen can lead to the rapid onset of potentially fatal anaphylaxis. In this thesis I address outstanding questions related to food allergies and their practical consequences using multiple modalities. First, I discuss the use of targeted mass spectrometry to answer a recurring question that plagues allergic consumers: is a food with precautionary allergen labeling, such as "may contain, " safe to consume? Second, I discuss the use of single-cell RNA sequencing to isolate and characterize rare B cells in a manner that informs our mechanistic understanding of allergic memory while also providing insight into individual IgE antibodies that directly mediate allergic reactivity.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Croote, Derek Matthew |
|---|---|
| Degree supervisor | Quake, Stephen Ronald |
| Thesis advisor | Quake, Stephen Ronald |
| Thesis advisor | Altman, Russ |
| Thesis advisor | Wang, Bo, (Researcher in bioengineering) |
| Degree committee member | Altman, Russ |
| Degree committee member | Wang, Bo, (Researcher in bioengineering) |
| Associated with | Stanford University, Department of Bioengineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Derek Matthew Croote. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Derek Matthew Croote
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...