Modern theory of protein folding

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Abstract/Contents

Abstract
Despite over half a century of study, many interesting questions concerning protein folding remain. I detail the gaps in our theoretical understanding of folding, describe how new theories and experiments could fill those gaps, and discuss my own attempts to understand one of biology's most amazing phenomena. Specifically, I discuss how master equations can be used to understand folding kinetics, how we can understand the surprising simplicity of folding kinetics, and how a experiments determining the rate-length law of folding could contribute to our ability to falsify theoretical arguments. I conclude with five stimulating questions that if answered would further our understanding of folding significantly.

Description

Type of resource text
Form electronic; electronic resource; remote
Extent 1 online resource.
Publication date 2015
Issuance monographic
Language English

Creators/Contributors

Associated with Lane, Thomas Joseph
Associated with Stanford University, Department of Chemistry.
Primary advisor Pande, Vijay
Thesis advisor Pande, Vijay
Thesis advisor Das, Rhiju
Thesis advisor Markland, Thomas E
Advisor Das, Rhiju
Advisor Markland, Thomas E

Subjects

Genre Theses

Bibliographic information

Statement of responsibility Thomas J. Lane.
Note Submitted to the Department of Chemistry.
Thesis Thesis (Ph.D.)--Stanford University, 2015.
Location electronic resource

Access conditions

Copyright
© 2015 by Thomas Joseph Lane
License
This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).

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