Supplemental Data for Mosca and Luo, 2014 (eLife): Raw Images of DA1
Abstract/Contents
- Abstract
Understanding information flow through neuronal circuits requires knowledge of their synaptic organization. In this study, we utilized fluorescent pre- and postsynaptic markers to map synaptic organization in the Drosophila antennal lobe, the first olfactory processing center. Olfactory receptor neurons (ORNs) produce a constant synaptic density across different glomeruli. Each ORN within a class contributes nearly identical active zone number. Active zones from ORNs, projection neurons (PNs), and local interneurons have distinct subglomerular and subcellular distributions. The correct number of ORN active zones and PN acetylcholine receptor clusters requires the Teneurins, conserved transmembrane proteins involved in neuromuscular synapse organization and synaptic partner matching. Ten-a acts in ORNs to organize presynaptic active zones via the spectrin cytoskeleton. Ten-m acts in PNs autonomously to regulate acetylcholine receptor cluster number and transsynaptically to regulate ORN active zone number. These studies advanced our ability to assess synaptic architecture in complex CNS circuits and their underlying molecular mechanisms.
For all images:
M = Male, F = Female, R = Right Antennal Lobe, L = Left Antennal Lobe
Or67d = DA1, OR88a = VA1d, Or47b = VA1lm, AM29 = DL4 and DM6
Description
Type of resource | software, multimedia |
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Date created | October 2014 |
Creators/Contributors
Author | Mosca, Timothy J., PhD |
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Subjects
Subject | Biology Department |
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Genre | Dataset |
Bibliographic information
Related Publication | Mosca, T.J., and Luo, L. (2014). Synaptic organization of the Drosophila antennal lobe and its regulation by the Teneurins. eLife 3, e03726. |
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Related item | |
Location | https://purl.stanford.edu/yq356jk9768 |
Access conditions
- Use and reproduction
- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
Preferred citation
- Preferred Citation
- Mosca, Timothy J., PhD. (2014). Supplemental Data for Mosca and Luo, 2014 (eLife): Raw Images of DA1. Stanford Digital Repository. Available at: http://purl.stanford.edu/yq356jk9768
Collection
Drosophila Antennal Lobe Synapses
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- Contact
- tmosca@stanford.edu
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