The differential roles of monocytes and neutrophils in inflammation-induced neurological dysfunction
Abstract/Contents
- Abstract
- Patients with inflammatory disorders frequently experience neurological complications including epilepsy, depression, attention deficit disorders, migraines, and dementia. However, the mechanistic basis for these associations is unknown. Given that many patients are unresponsive to existing medications or experience debilitating side effects, novel therapeutics that target the underlying pathophysiology of these conditions are urgently needed. There are many hypotheses as to why peripheral inflammation and neurological conditions co-occur; however, there have been few mechanistic studies demonstrating a causal relationship, and investigations of these mechanisms have yielded contradictory results. Further, neuroinflammation can exist in patients with neurological disorders who do not have a diagnosed autoinflammatory disease. Because the vast majority of studies investigating the occurrence and impact of neuroinflammation on brain function have utilized models of primary neurological disease, it is difficult to uncouple the role of the primary neurological pathology from that of inflammation. To more clearly understand the mechanisms by which peripheral inflammatory disease causes neurological symptoms, it is therefore necessary to employ models of peripheral inflammation in which the brain is not initially involved. In this thesis, I utilize a murine colitis model in which colitic mice demonstrate enhanced seizure susceptibility to untangle the differential role of monocytes and neutrophils on neurological dysfunction in the absence of a primary neurological disorder. I further present investigations into the neuroinflammatory phenotype of patients with epilepsy and pediatric acute-onset neuropsychiatric syndrome (PANS).
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Barnes, Sarah Elizabeth |
|---|---|
| Degree supervisor | Engleman, Edgar G |
| Thesis advisor | Engleman, Edgar G |
| Thesis advisor | Bendall, Sean, 1979- |
| Thesis advisor | Buckwalter, Marion |
| Thesis advisor | Mellins, Elizabeth |
| Degree committee member | Bendall, Sean, 1979- |
| Degree committee member | Buckwalter, Marion |
| Degree committee member | Mellins, Elizabeth |
| Associated with | Stanford University, Program of Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Sarah Elizabeth Barnes. |
|---|---|
| Note | Submitted to the Program of Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/yp749ws6875 |
Access conditions
- Copyright
- © 2021 by Sarah Elizabeth Barnes
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...