Dissecting the neural mechanisms of cerebellum-dependent learning : enhanced plasticity and instructive signals

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The focus of this thesis is to understand the contribution of multiple learning mechanisms to cerebellum-dependent motor learning. The studies that contribute to this thesis examine the role multiple learning mechanisms in the context of signaling in the intact circuit of awake-behaving animals. By using a well-parameterized learning paradigm, it is possible to distinguish and separate the contribution of specific learning mechanisms to different aspects of learning. This thesis demonstrates the sufficiency to two learning mechanisms long hypothesized to be important for cerebellum-dependent learning: 1) LTD at the parallel fiber to Purkinje cell synapse in the cortex (Marr 1969; Albus 1971; Ito 1972); and 2) the output of Purkinje cell simple spike activity (Miles & Lisberger 1981). Furthermore, the findings highlight the importance of understanding how learning mechanisms operate in vivo and interact with the on-going activity as well as previous activity in the circuit to determine different learning outcomes. The idea that the properties of a learning mechanism do not operate in isolation to produce learning but must be considered in the context of the intact and functional circuit is a common lesson that could apply to and should be tested in other learning systems of the brain.


Type of resource text
Form electronic; electronic resource; remote
Extent 1 online resource.
Publication date 2012
Issuance monographic
Language English


Associated with Nguyen-Vu, T.D. Barbara
Associated with Stanford University, Program in Molecular and Cellular Physiology.
Primary advisor Raymond, Jennifer L
Thesis advisor Raymond, Jennifer L
Thesis advisor Madison, Daniel V, 1956-
Thesis advisor Moore, Tirin, 1969-
Thesis advisor Shatz, Carla J
Advisor Madison, Daniel V, 1956-
Advisor Moore, Tirin, 1969-
Advisor Shatz, Carla J


Genre Theses

Bibliographic information

Statement of responsibility T.D. Barbara Nguyen-Vu.
Note Submitted to the Program in Molecular and Cellular Physiology.
Thesis Thesis (Ph.D.)--Stanford University, 2012.
Location electronic resource

Access conditions

© 2012 by T.D. Barbara Nguyen-Vu
This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

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