The design, synthesis and evaluation of guanidinium-rich molecular transporters for the delivery of antibiotics and oligonucleotides
Abstract/Contents
- Abstract
- The delivery of cell-impenetrable therapeutic agents across biological barriers represents a challenging problem in the field of life science research and medicine. Many bacterial pathogens are inherently resistant to glycopeptide antibiotics such as vancomycin due to the antibiotic's relatively large size and mode of action, which requires actively growing cells. Recently, genetically-resistant vancomycin strains have emerged, adding to vancomycin's inefficaciousness against certain bacterial populations. The emergence and understanding of phenotypically and genetically resistant bacteria coupled to a declining pipeline of antibiotic development necessitates new strategies to combat bacterial infections. As part of a collaboration between the Wender and Cegelski labs, we have designed, synthesized and evaluated a novel vancomycin cell-penetrating peptide conjugate. We have shown that this new conjugate exhibits a unique mode of action compared to vancomycin, allowing it to be extremely effective against vancomycin-insensitive bacterial populations.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Huttner, Melanie Ann |
|---|---|
| Degree supervisor | Wender, Paul A |
| Thesis advisor | Wender, Paul A |
| Thesis advisor | Burns, Noah |
| Thesis advisor | Waymouth, Robert M |
| Degree committee member | Burns, Noah |
| Degree committee member | Waymouth, Robert M |
| Associated with | Stanford University, Department of Chemistry. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Melanie Ann Huttner. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Melanie Ann Huttner
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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