The evolution and demography of X-linked and GWAS SNPs
- Population geneticists have used genome-wide single nucleotide polymorphism (SNP) datasets to investigate the demographic history of humans and to identify regions of the human genome subject to selection. While some general statements can be made about genome as a whole, every genomic locus has its own evolutionary history. The work contained in this dissertation is aimed at elucidating this history for two particular SNP subsets. The first two chapters explore the effects of selection on the X chromosome. Chapter 1 presents evidence that the X chromosome is more frequently a target of selection than the autosomes and identifies regions of the chromosome where selection may have acted. Chapter 2 explores the evolutionary history of one of these regions in depth through haplotype analyses. Chapter 3 investigates the role of selection in the evolution of SNPs with phenotypic associations and finds evidence for selection on SNPs associated with pigmentation, blood pressure, autoimmune disease, and infectious disease susceptibility. Overall, this work as a whole reinforces the conclusion that natural selection acts unevenly throughout the genome and presents evidence for selection on two subsets of genome-wide SNP datasets: X-linked SNPs and SNPs with phenotypic associations.
|Type of resource
|electronic; electronic resource; remote
|1 online resource.
|Casto, Amanda Morgan
|Stanford University, Department of Genetics
|Feldman, Marcus W
|Feldman, Marcus W
|Statement of responsibility
|Amanda Morgan Casto.
|Submitted to the Department of Genetics.
|Thesis (Ph.D.)--Stanford University, 2012.
- © 2012 by Amanda Morgan Casto
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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