Design of a Current Source for Low-Power Electromagnet Excitation in Giant Magnetoresistive-based Biosensors

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Abstract/Contents

Abstract: Rapid biomarker identification and detection at low concentrations in biological fluids opens the door to early-detection and treatment of not only chronic diseases that develop over many years, but also acute infectious diseases where rapid diagnosis is often a necessity. To enable rapid-testing, high sensitivity biosensors have to be moved to the point-of-care (POC). One of the most sensitive biosensors cited in literature are giant-magneto-resistive spin-valve (GMR-SV) biosensors. Proof-of-concept point-of-care GMR platforms have been developed but suffer from high power consumption and low in-field life-time. To transfer this GMR biosensor into a point-of-care setting for DNA detection it must be readily integrated with a method of DNA amplification, such as polymerase-chain reaction (PCR). PCR is also a very power-intensive process needed for sample preparation for sensing and analysis, further constraining the power budget of the GMR system and increasing the sizes, voltages, currents, and converter sizes for a deployable POC device. This honors thesis aims to significantly decrease the power consumption needed for the PCR-GMR POC platform by (1) decreasing the power budget needed for GMR-biosensor readout, (2) improving efficiency of on-board voltage conversion and regulation, and (3) exploring the feasibility and opportunity in integrating PCR and GMR into a single die using multi-physics simulations.

Type of resource	text
Date created	January 2020 - May 2021

Author	Lall, Rahul Kartikeya
Advisor	Yao, Bryce
Advisor	Wang, Shan
Degree granting institution	Stanford University, Department of Electrical Engineering

Location	https://purl.stanford.edu/yb973nc1670

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License: This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

Preferred Citation: Lall, Rahul Kartikeya. Design of a Current Source for Low-Power Electromagnet Excitation in Giant Magnetoresistive-based Biosensors. Stanford Digital Repository. Available at: https://purl.stanford.edu/yb973nc1670

Undergraduate Theses, School of Engineering

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