Epidemiology, natural history, and cancer prevention of non-alcoholic fatty liver disease
Abstract/Contents
- Abstract
- Non-alcoholic fatty liver disease (NAFLD) is defined by the presence of excessive hepatic steatosis (> 5%) in the absence of other identifiable causes, including excessive alcohol use and viral hepatitis. It is a major cause of chronic liver disease globally with a prevalence of 29.8% and 35.7% for the United States. NAFLD also carries a substantial health, economic, and patient reported outcome burden. The overall goal of this dissertation is to use different statistical and epidemiological methods to study the epidemiology, natural history, and cancer prevention of NAFLD. In the first part of the dissertation, we applied the meta-analysis method to estimate the prevalence, incidence, clinical characteristics, and outcome of NAFLD in the Asian population. The evidence can assist stakeholders in understanding disease burden of NAFLD in Asia. In the second part, we investigated the prevalence and outcome data for non-obese NAFLD for the multiethnic US population and discovered that non-obese individuals with NAFLD had significantly higher all-cause mortality than obese individuals with NAFLD. Finally, we applied the causal inference method to determine the association between statin initiation and the risk of live cancer among patients with NAFLD. These chapters demonstrated NAFLD is truly becoming a global disease burden and future studies should be devoted to investigating the prevention and treatment of NAFLD.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Zou, Biyao |
|---|---|
| Degree supervisor | Nguyen, Mindie |
| Degree supervisor | Odden, Michelle |
| Thesis advisor | Nguyen, Mindie |
| Thesis advisor | Odden, Michelle |
| Thesis advisor | Sainani, Kristin |
| Thesis advisor | Wang, Shan X |
| Degree committee member | Sainani, Kristin |
| Degree committee member | Wang, Shan X |
| Associated with | Stanford University, Department of Epidemiology and Population Health |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Biyao Zou. |
|---|---|
| Note | Submitted to the Department of Epidemiology and Population Health. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/xv860nh6119 |
Access conditions
- Copyright
- © 2022 by Biyao Zou
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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