A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow (second)

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Abstract/Contents

Abstract: Spatial and temporal patterns in the structure of microbial communities provide insights into the forces that shape these communities, their functions, and their roles in health and disease. Here, we used spatial and ecological statistics with microbiota community composition data at high spatial resolution from more than 9,000 dental and mucosal samples to examine the role that saliva plays in structuring bacterial communities of the human mouth. We show that regardless of tissue type (teeth, alveolar mucosa, keratinized gingiva, buccal mucosa), surface-associated bacterial communities vary along an ecological gradient from the front of the mouth to the back, and that on exposed tooth surfaces, the gradient is most pronounced on lingual compared to buccal surfaces. Furthermore, our data suggest that this gradient is attenuated in individuals with low salivary flow due to Sjögren’s Syndrome. Interestingly, these individuals have communities enriched in caries-associated bacteria despite the absence of active dental caries at the time of sample collection. Taken together, these findings suggest that salivary flow influences the spatial organization of microbial communities and that biogeographical patterns may be useful for understanding host physiological processes and for predicting disease.

Type of resource	software, multimedia
Date created	[ca. January 1, 2012 - December 17, 2017]

Related Publication	Proctor, D. M., Fukuyama, J. A., Loomer, P. M., Armitage, G. C., Lee, S. A., Davis, N. M., Ryder, M. I., Holmes, S. P., Relman, D. A. 2018. A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow. Nature Communications 9(1). http://doi.org/10.1038/s41467-018-02900-1
Location	https://purl.stanford.edu/xr749qy9885

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License: This work is licensed under a Creative Commons Attribution Non Commercial Share Alike 3.0 Unported license (CC BY-NC-SA).

Preferred Citation: Proctor, Diana M. and Fukuyama, Julia A. and Loomer, Peter M. and Armitage, Gary C. and Lee, Stacey A. and Davis, NM and Ryder, Mark I. and Holmes, Susan P. and Relman, David A.. (2017). A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow (second). Stanford Digital Repository. Available at: https://purl.stanford.edu/xr749qy9885

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