Understanding the link of arterial structure and functional outcomes during growth and regeneration
Abstract/Contents
- Abstract
- The coronary arterial vasculature undergoes distinct developmental phases to reach its adult structure. Coronary arteries (CAs) have an inner cellular layer composed of endothelial cells. These cells are specified early in development before blood flows through the primitive coronary vasculature. Subsequently, the arterial network matures and experiences significant expansion during its initial weeks of life, defining its final architecture. The chapters in this study reflect the approaches used to understand the connection between arterial structure and functional outcomes during growth and regeneration. In these projects, our objectives are to determine the cellular origins of the CA tree, examine how CAs structure influences function, and investigate the response of CA architecture to injury. By utilizing advanced whole-organ and clearing imaging techniques, we examined the entire artery network and discovered that specific endothelial cells in the coronary capillary bed are predisposed to transform into arterial cells during postnatal growth. Furthermore, we observed that neonatal coronary arteries exhibit distinct responses to injury and collateral artery development, which may explain their superior regenerative capabilities compared to adult arteries. Lastly, we investigated the genetic variant associated with coronary artery dominance in humans to explore its causality. This research illuminates the structure and development of coronary arteries, with implications for cardiovascular medicine.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Rios Coronado, Pamela Elizabeth |
|---|---|
| Degree supervisor | Red-Horse, Kristy |
| Thesis advisor | Red-Horse, Kristy |
| Thesis advisor | O'Connell, Lauren |
| Thesis advisor | Wang, Bo |
| Thesis advisor | Wu, Sean |
| Degree committee member | O'Connell, Lauren |
| Degree committee member | Wang, Bo |
| Degree committee member | Wu, Sean |
| Associated with | Stanford University, School of Humanities and Sciences |
| Associated with | Stanford University, Department of Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Pamela E. Rios Coronado. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/xk638vj7759 |
Access conditions
- Copyright
- © 2023 by Pamela Elizabeth Rios Coronado
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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