Bioinspired melanin nanoparticles for multimodality imaging and biocatalysis
Abstract/Contents
- Abstract
- Water-soluble melanin dots (M-dots) have been developed and synthesized as the nanoplatform for multimodal imaging. Gadolinium (III) loaded M-dots (Gd-M-dots) are proven to be highly sensitive, biocompatible, stable, and multimodal imaging probes without noticeable Gd3+ toxicity. Furthermore, Gd-M-dots showed unique photoacoustic (PA) properties. Compared to the traditional Gd3+-loaded nanoparticles for single-modal MRI, Gd-M-dots can also be radiolabeled with 64Cu2+ for positron emission tomography. Gd-M-dots also exhibit dual contrast enhancing capabilities. In vitro and in vivo studies indicate that Gd-M-dots can be used as a dual T1 and T2 MRI contrast agent with high r1 and r2 relaxivity. Gd-M-dots have a high potential to be a valuable contrast agent for detection and differentiation of tumors, a blood pool contrast agent for MR venography and nanoplatform for tumor diagnostic and therapeutic applications. M-dots can also serve as an effective nanoplatform for preparing a ligand-free and water-soluble heterogeneous catalyst, Cu(I)/M-dots. Cu(I)/M-dots are proven to be a high performance, biocompatible and recyclable catalytic system for CuAAC and bioconjugation without any Cu(I) toxicity. M-dots can serve as a novel metal-loading recyclable catalyst for various applications in bioconjugation and chemical biology.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2017 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Hong, Su Hyun |
|---|---|
| Associated with | Stanford University, Department of Chemistry. |
| Primary advisor | Cheng, Zhen, 1973- |
| Thesis advisor | Cheng, Zhen, 1973- |
| Thesis advisor | Graves, Edward (Edward Elliot), 1974- |
| Thesis advisor | Stack, T. (T. Daniel P.), 1959- |
| Advisor | Graves, Edward (Edward Elliot), 1974- |
| Advisor | Stack, T. (T. Daniel P.), 1959- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Su Hyun Hong. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2017. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2017 by Su Hyun Hong
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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