Part I: carbon monoxide reduction at gas diffusion electrodes ; Part II: development of a point-of-care device for blood ammonia measurement
Abstract/Contents
- Abstract
- Part I: Carbon Monoxide Reduction at Gas Diffusion Electrodes: Anthropogenic climate change is one of the grand challenges facing humankind today. Although renewable energy sources are enjoying increasing adoption, issues with curtailment of excess energy, intermittency, and the present energy infrastructure's reliance on liquid fuels prevent their widespread deployment. Electrochemical carbon monoxide reduction to liquid fuel offers a promising pathway to bridge the gap between renewable energy sources and liquid fuels. Presently, only copper is known to efficiently perform these transformations, and results are confined to small-scale laboratory demonstrations owing to carbon monoxide's poor solubility in water. For the first time, gas diffusion electrodes based on copper catalysts have been shown to overcome this limitation, demonstrating that the underlying chemistry can scale favorably despite low solubility, and positioning carbon monoxide reduction as a transformative technology capable of hastening the deployment of renewable energy. Part II: Development of a Point-of-Care Device for Blood Ammonia Measurement: Hyperammonemia (elevated blood ammonia) is a life-threatening medical emergency that will result in permanent brain damage if untreated. Although a variety of effective treatment options exist, measurement of ammonia in the blood remains challenging as the only clinically-validated measurement is plagued by issues of significant interferences and sample instability. In this work, a handheld point-of-care instrument using an orthogonal detection scheme is developed and shown to be superior to the standard-of-care technology. The ultimate device can measure ammonia in 10 µL of a biological sample in less than 30 seconds. This handheld device opens the door to fingerstick blood ammonia measurements, thereby meeting the critical unmet need in the treatment of hyperammonemia.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Veltman, Thomas Richard |
|---|---|
| Associated with | Stanford University, Department of Chemistry. |
| Primary advisor | Kanan, Matthew William, 1978- |
| Thesis advisor | Kanan, Matthew William, 1978- |
| Thesis advisor | Du Bois, Justin |
| Thesis advisor | Stack, T. (T. Daniel P.), 1959- |
| Advisor | Du Bois, Justin |
| Advisor | Stack, T. (T. Daniel P.), 1959- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Thomas Richard Veltman. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Thomas Richard Veltman
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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