Mechanics of the mitral valve - an in vivo/in silico approach
- The mitral valve is one of four heart valves that ensure unidirectional blood flow through the heart. Due to mitral valve failure approximately 44,000 people in the US alone undergo open heart surgery every year. Current treatment options include mitral valve replacement and mitral valve repair, neither of which have shown satisfying long-term success. A deepened understanding of mitral valve mechanics may help in improving current medical device designs and treatment options for mitral valve regurgitation. Here I provide an in depth analysis of the in vivo mechanics of the mitral valve using the theory of finite kinematics and based on this data develop non-linear in silico models of the mitral valve employing the finite element method. Using mechanical metrics such as strain and curvature I reveal the in vivo deformation of the mitral annulus and the mitral leaflet in the healthy, diseased, and repaired mitral valve. Furthermore, in silico I explore the effects of prestrain as well as growth and remodeling on the mechanics of the mitral valve. The results of my in vivo studies extend our current understanding of the healthy mitral valve, reveal new insight into disease characteristics and progressions, and evaluate the efficacy of current device designs. Furthermore, results from the in silico studies provide improved means to simulate mitral valve mechanics and predict long term adaptation for basic science research and medical device design. In conclusion, with the current work I take a large step toward a deepened understanding of mitral valve mechanics that may help to optimize medical device designs and treatment options.
|Type of resource
|electronic; electronic resource; remote
|1 online resource.
|Rausch, Manuel K
|Stanford University, Department of Mechanical Engineering.
|Kuhl, Ellen, 1971-
|Kuhl, Ellen, 1971-
|Statement of responsibility
|Manuel K. Rausch.
|Submitted to the Department of Mechanical Engineering.
|Thesis (Ph.D.)--Stanford University, 2013.
- © 2013 by Manuel Karl Rausch
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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