Enhancing humoral immunity with injectable hydrogel platforms for sustained vaccine exposure
Abstract/Contents
- Abstract
- Existing and emerging infectious diseases continue to threaten our population. While vaccine development has progressed over the last several decades, there is still a critical need for improving immunomodulatory technologies to guide the endogenous immune response. As our knowledge of the immune system deepens, it is becoming clear that vaccine components must be in the right place at the right time to orchestrate a potent and durable response. Yet, increasing the potency, quality, and durability of the vaccine response remains a challenge. Material platforms such as nanoparticles, hydrogels, and microneedles can be engineered to spatially and temporally control the interactions of vaccine components with immune cells. Given their emerging role as immunomodulatory tools, these materials have been shown to augment the vaccine immune response by improving innate immune cell activation, creating local inflammatory niches, targeting delivering to lymph nodes, and controlling the timeframe of vaccine delivery. This chapter highlights the critical biological mechanisms for developing a strong humoral immune response and explores how materials have been designed to manipulate them.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Roth, Gillie Agmon |
|---|---|
| Degree supervisor | Appel, Eric (Eric Andrew) |
| Thesis advisor | Appel, Eric (Eric Andrew) |
| Thesis advisor | Pulendran, B. (Bali) |
| Thesis advisor | Yang, Fan, (Bioengineering researcher and teacher) |
| Degree committee member | Pulendran, B. (Bali) |
| Degree committee member | Yang, Fan, (Bioengineering researcher and teacher) |
| Associated with | Stanford University, Department of Bioengineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Gillie Agmon Roth. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2020. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Gillie Agmon Roth
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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