Genetic regulation and evolution of gene expression
Abstract/Contents
- Abstract
- Since the early 20th century, a core goal of biology has been understanding the connection between genotype and phenotype. A deep understanding of this link could help inform our understanding of disease etiology and potential mechanisms for evolutionary adaptation. Here, I extend our knowledge of the genotype-phenotype connection in three ways. In the first two chapters I leverage the genotype-phenotype intermediary of mRNA expression to identify genetic loci that control mRNA expression in an age dependent manner (Chapter 1), and that control sets of genes rather than individual genes (Chapter 2). These loci's phenotypic consequences are assessed and in both cases we observed enrichment for loci relevant to human disease. In Chapter 3, I again leverage mRNA expression but now using measurement across diverse eukaryotic species in order to identify novel genes that share coordinated evolution and thus likely functional associations.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2017 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Martin, Trevor |
|---|---|
| Associated with | Stanford University, Department of Biology. |
| Primary advisor | Fraser, Hunter B |
| Thesis advisor | Fraser, Hunter B |
| Thesis advisor | Montgomery, Stephen, 1979- |
| Thesis advisor | Petrov, Dmitri Alex, 1969- |
| Advisor | Montgomery, Stephen, 1979- |
| Advisor | Petrov, Dmitri Alex, 1969- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Trevor Martin. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2017. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2017 by Trevor McCarter Martin
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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