Genetic regulation and evolution of gene expression

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Since the early 20th century, a core goal of biology has been understanding the connection between genotype and phenotype. A deep understanding of this link could help inform our understanding of disease etiology and potential mechanisms for evolutionary adaptation. Here, I extend our knowledge of the genotype-phenotype connection in three ways. In the first two chapters I leverage the genotype-phenotype intermediary of mRNA expression to identify genetic loci that control mRNA expression in an age dependent manner (Chapter 1), and that control sets of genes rather than individual genes (Chapter 2). These loci's phenotypic consequences are assessed and in both cases we observed enrichment for loci relevant to human disease. In Chapter 3, I again leverage mRNA expression but now using measurement across diverse eukaryotic species in order to identify novel genes that share coordinated evolution and thus likely functional associations.


Type of resource text
Form electronic; electronic resource; remote
Extent 1 online resource.
Publication date 2017
Issuance monographic
Language English


Associated with Martin, Trevor
Associated with Stanford University, Department of Biology.
Primary advisor Fraser, Hunter B
Thesis advisor Fraser, Hunter B
Thesis advisor Montgomery, Stephen, 1979-
Thesis advisor Petrov, Dmitri Alex, 1969-
Advisor Montgomery, Stephen, 1979-
Advisor Petrov, Dmitri Alex, 1969-


Genre Theses

Bibliographic information

Statement of responsibility Trevor Martin.
Note Submitted to the Department of Biology.
Thesis Thesis (Ph.D.)--Stanford University, 2017.
Location electronic resource

Access conditions

© 2017 by Trevor McCarter Martin
This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

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