The many roles of protein methylation in MRna translation and human cancer biology
Abstract/Contents
- Abstract
- The human genes eEF1A and eEF2 encode essential enzymes that facilitate one of the most fundamental processes in biology: mRNA translation elongation. Both eEF1A and eEF2 are targets of lysine methylation. The lysine methyltransferase (KMT) enzymes that target eEF1A and eEF2 are commonly associated with human cancers. Given the possibility that these methylation events contribute to human disease, it's imperative to determine what their molecular functions are. The work described in this dissertation partially characterizes the biological functions of eEF1A and eEF2 methylation in mRNA translation and cancer. Further, this work leverages a new artificial intelligence technology, AlphaFold, to characterize the physical FAM86A-eEF2 interaction, advancing the possibility of developing a highly specific FAM86A inhibitor for therapeutic use.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Francis, Joel William |
|---|---|
| Degree supervisor | Gozani, Or |
| Thesis advisor | Gozani, Or |
| Thesis advisor | Frydman, Judith |
| Thesis advisor | Morrison, Ashby |
| Thesis advisor | Winslow, Monte |
| Degree committee member | Frydman, Judith |
| Degree committee member | Morrison, Ashby |
| Degree committee member | Winslow, Monte |
| Associated with | Stanford University, School of Humanities and Sciences |
| Associated with | Stanford University, Department of Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Joel William Francis. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/wf813kk6843 |
Access conditions
- Copyright
- © 2023 by Joel William Francis
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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