The origins of diversity in the adaptive immune system and the brain
Abstract/Contents
- Abstract
- Multicellular organisms are composed of many individual cells having diverse form and function. Even though differences between cells are essential for tissue and organism function, the processes that create and shape cellular diversity remain poorly understood in many living systems. Here, I explore cellular diversity in the adaptive immune system and the brain. In my work on human antibodies, I showed how somatic evolution unfolding in B cell populations generates and focuses the diversity of the antibody repertoire, enabling highly sensitive and specific recognition of foreign molecules. I also examined how antibody diversity is related to the transcriptional programs and clonal population dynamics of B cells. Finally, I comprehensively mapped the landscape of antibody class switch recombination, showing how antibodies of different classes are created in living humans and revealing cellular mechanisms that control class switch fate. In the developing fruit fly brain, using single-cell transcriptional profiling and genetic labeling strategies, I demonstrated that the transcriptional identity of individual neurons corresponds well to their anatomical and physiological function, and illuminated several principles of cell identity in neural development.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Horns, Richard Felix |
|---|---|
| Degree supervisor | Quake, Stephen Ronald |
| Thesis advisor | Quake, Stephen Ronald |
| Thesis advisor | Kim, Peter, 1958- |
| Thesis advisor | Pritchard, Jonathan D |
| Degree committee member | Kim, Peter, 1958- |
| Degree committee member | Pritchard, Jonathan D |
| Associated with | Stanford University, Biophysics Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Richard Felix Horns. |
|---|---|
| Note | Submitted to the Program in Biophysics. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Richard Felix Horns
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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