Innate immune control of liver regeneration
Abstract/Contents
- Abstract
- Eosinophil-derived IL-4 stimulates hepatocyte proliferation to promote liver regeneration Abstract It has been proposed that allergic immune responses, like those mediated by type 2 immunity, evolved to protect the host from damage caused by environmental challenges, including toxins, xenobiotics, and helminth infections (1, 2). Despite some support for this hypothesis (3, 4), the underlying mechanisms by which type 2 innate responses orchestrate the regeneration of injured tissues remain largely unknown. Here, we demonstrate a requirement for type 2 innate immunity in regeneration of liver after partial hepatectomy and toxin-mediated injury. Injury to liver results in rapid recruitment of eosinophils, which secrete IL-4 to promote the proliferation of quiescent hepatocytes. Surprisingly, signaling via the IL-4R[alpha] in macrophages, which have been implicated in tissue repair (3-5), is dispensable for hepatocyte proliferation and liver regrowth after injury. Instead, IL-4 exerts its mitogenic actions by directly activating IL-4R[alpha] in hepatocytes. Our findings have thus uncovered an unexpected mechanism by which allergic type 2 innate immunity stimulates hepatocyte proliferation to promote liver regeneration.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2013 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Goh, Yun Pei Sharon |
|---|---|
| Associated with | Stanford University, Program in Immunology. |
| Primary advisor | Steinman, Lawrence |
| Thesis advisor | Steinman, Lawrence |
| Thesis advisor | Chawla, Ajay |
| Thesis advisor | Galli, Stephen J |
| Thesis advisor | Martinez, Olivia |
| Advisor | Chawla, Ajay |
| Advisor | Galli, Stephen J |
| Advisor | Martinez, Olivia |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Yun Pei Sharon Goh. |
|---|---|
| Note | Submitted to the Program in Immunology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2013. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2013 by Yun Pei Sharon Goh
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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