Characterizing mouse aging organism-wide with RNA-sequencing and single-cell RNA-sequencing
Abstract/Contents
- Abstract
- The cellular and molecular damage that defines aging is the single greatest cause of disease and suffering worldwide. Here I describe my initial efforts to unravel these complexities and characterize aging across all major organs and cell types in the mouse, Mus Musculus. This work so far encompasses single-cell RNA-sequencing in young mice, a database termed Tabula Muris, and whole organ RNA-sequencing at 10 ages across the lifespan, with single-cell RNA-sequencing across the lifespan currently underway. Tabula Muris provides a key transcriptomic resource for the field, and the whole organ transcriptomics unveil distinct aging dynamics among organ never before observed. Altogether, it is my hope that these data and findings will accelerate the development of therapies that keep us healthier, longer.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Schaum, Nicholas Donald |
|---|---|
| Degree supervisor | Wyss-Coray, Anton |
| Thesis advisor | Wyss-Coray, Anton |
| Thesis advisor | Palmer, Theo |
| Thesis advisor | Rando, Thomas A |
| Degree committee member | Palmer, Theo |
| Degree committee member | Rando, Thomas A |
| Associated with | Stanford University, Department of Stem Cell Biology and Regenerative Medicine Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Nicholas Donald Schaum. |
|---|---|
| Note | Submitted to the Department of Stem Cell Biology and Regenerative Medicine Program. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Nicholas Donald Schaum
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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