Systemic tumor immunity across tumor development and metastatic progression
Abstract/Contents
- Abstract
- The study of tumor immunology has led to great successes in the advancement of effective cancer treatments. Despite these advances, there are still tumor types and patient populations that remain unresponsive to current immunotherapies. My studies are intended to better understand the mechanisms and consequences of tumor-immune cell interactions. The studies in Chapter 1 demonstrate that effective immune responses maintain activation and proliferation of lymphocytes in the periphery rather than the tumor microenvironment. This work provides insight into the mechanisms of effective immunotherapy responses in solid tumors while also demonstrating the importance of taking a system-wide approach to such studies. We then use a mouse model of lymph node metastasis developed in our lab to investigate the factors that enable primary tumor cells to survive immune attack as they traffic to the draining lymph nodes. Based on this work we introduce our "Metastatic Tolerance" model which describes that lymph node colonization induces systemic tumor-immune tolerance and thus enables distant metastasis. In chapter two I expand on our model of metastatic tolerance by identifying B cells as an important cell type in both melanoma lymph node metastasis and tolerance induction. In chapter three I once again take a system-wide approach to demonstrate how specific genotypes, specifically Kras mutation and Trp53 deletion, alter immune responses in pancreatitis prior to the development of pancreatic ductile adenocarcinoma.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Martins, Maria Margarida |
|---|---|
| Degree supervisor | Engleman, Edgar G |
| Thesis advisor | Engleman, Edgar G |
| Thesis advisor | Attardi, Laura |
| Thesis advisor | Bendall, Sean, 1979- |
| Thesis advisor | Winslow, Monte |
| Degree committee member | Attardi, Laura |
| Degree committee member | Bendall, Sean, 1979- |
| Degree committee member | Winslow, Monte |
| Associated with | Stanford University, Cancer Biology Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Maria M. Martins. |
|---|---|
| Note | Submitted to the Cancer Biology Program. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/vs849gv6060 |
Access conditions
- Copyright
- © 2022 by Maria Margarida Martins
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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