Transient reprogramming for multifaceted reversal of aging phenotypes
Abstract/Contents
- Abstract
- Though aging is generally associated with tissue and organ dysfunction, these can be considered the emergent consequences of fundamental transitions in the state of cellular physiology. These transitions have multiple manifestations at different levels of cellular architecture and function but the central regulator of these transitions is the epigenome, the most upstream dynamic regulator of gene expression. Reproduction is the only general phenomena in nature where the age of (parental) cells is truly reset - to produce an embryo and ultimately an age 0 offspring - and core to this process is a dramatic reprogramming of the epigenome. Here we present a technology that captures part of this age reset mechanism but using a transient reprogramming - to drive more youthful phenotypes but without the full reset back to an embryo. This reprogramming technology is distinct from previous anti-aging/pro-longevity interventions as instead of just modulating a few identified aging pathways, reprogramming engages a global and balanced state transition, in the case of reproduction, or state perturbation, in our transient approach, which we show leads to a multifaceted age reversal effect at the DNA, metabolic, whole cell and local environmental levels. We further discuss the emergent tissue and organ level benefits when transplanted with cells undergoing this treatment.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Sarkar, Tapash Jay |
|---|---|
| Degree supervisor | Sebastiano, Vittorio |
| Degree supervisor | Spakowitz, Andrew James |
| Thesis advisor | Sebastiano, Vittorio |
| Thesis advisor | Spakowitz, Andrew James |
| Thesis advisor | Mahajan, Vinit |
| Degree committee member | Mahajan, Vinit |
| Associated with | Stanford University, Department of Applied Physics. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Tapash Sarkar. |
|---|---|
| Note | Submitted to the Department of Applied Physics. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Tapash Jay Sarkar
Also listed in
Loading usage metrics...