Functional dissection of the Cbln family of synaptic cell-adhesion molecules
Abstract/Contents
- Abstract
- Precise control of synapse formation and specification is required for the normal development and functioning of neural networks, and consequently, for cognition, emotion, and behavior. Trans-synaptic cell-adhesion molecules are understood to play an essential role in the formation, specification, and functioning of synapses. Cerebellins are a family of secreted proteins (Cbln1-Cbln4) that act as trans-synaptic cell-adhesion molecules by binding to presynaptic neurexins and postsynaptic receptors. In the cerebellum, Cbln1 is secreted from presynaptic granule cells and functions as a trans-synaptic organizer of parallel fiber-Purkinje cell synapses. Although the essential function of Cbln1 in cerebellar parallel-fiber synapses is well studied, little is known about the function of cerebellins outside the cerebellum and even less is known about the function of Cbln2 and Cbln4. In this dissertation, I will address these issues by using a combination of techniques to systematically dissect the expression profile and function of Cbln1, Cbln2, and Cbln4 throughout the brain. Taken together, I will show that all three cerebellins contribute to brain function, and that cerebellins act as important synaptic organizers in specific subsets of neurons throughout the brain.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Seigneur, Erica Michelle |
|---|---|
| Degree supervisor | Südhof, Thomas C |
| Thesis advisor | Südhof, Thomas C |
| Thesis advisor | Brünger, Axel T |
| Thesis advisor | Chen, Lu, (Professor of neurosurgery) |
| Thesis advisor | Luo, Liqun, 1966- |
| Thesis advisor | Malenka, Robert C |
| Degree committee member | Brünger, Axel T |
| Degree committee member | Chen, Lu, (Professor of neurosurgery) |
| Degree committee member | Luo, Liqun, 1966- |
| Degree committee member | Malenka, Robert C |
| Associated with | Stanford University, Neurosciences Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Erica Michelle Seigneur. |
|---|---|
| Note | Submitted to the Neurosciences Program. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Erica Michelle Seigneur
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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