Navigating the spinal skeletal stem cell microenvironment : insights for targeted tissue regeneration
Abstract/Contents
- Abstract
- The intervertebral disc (IVD), also known as the spinal disc, undergoes accelerated degeneration compared to other connective tissues, leading to intervertebral disc degeneration. Addressing this challenge requires effective treatments capable of reversing fibrocartilage damage caused by factors such as age and injury. Tissue-resident stem cells hold promise for IVD treatment due to their self-renewal and differentiation properties. In this dissertation, I will discuss our efforts to identify novel regulators of spinal skeletal stem cell (SSC) differentiation and their role in regenerating IVD tissue in response to injury. Additionally, I will outline a protocol we developed for isolating and functionally assessing human SSCs from various cell and tissue sources. Our basic and preclinical findings lay the foundation for innovative stem cell-based therapies targeting IVD degeneration and other related disorders.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2024; ©2024 |
| Publication date | 2024; 2024 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Hoover, Malachia Yvonne |
|---|---|
| Degree supervisor | Longaker, Michael T |
| Thesis advisor | Longaker, Michael T |
| Thesis advisor | Bhutani, Nidhi |
| Thesis advisor | Palmer, Theo |
| Thesis advisor | Weissman, Irving L |
| Degree committee member | Bhutani, Nidhi |
| Degree committee member | Palmer, Theo |
| Degree committee member | Weissman, Irving L |
| Associated with | Stanford University, School of Medicine |
| Associated with | Stanford University, Institute for Stem Cell Biology and Regenerative Medicine |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Malachia Hoover. |
|---|---|
| Note | Submitted to the Institute for Stem Cell Biology and Regenerative Medicine. |
| Thesis | Thesis Ph.D. Stanford University 2024. |
| Location | https://purl.stanford.edu/vq576bb4130 |
Access conditions
- Copyright
- © 2024 by Malachia Yvonne Hoover
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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