Investigating the neural basis of approach-avoidance conflict
Abstract/Contents
- Abstract
- Approach-avoidance conflict (AAC) arises from decisions with embedded positive and negative outcomes, and appropriate management of these decisions is essential for adaptive functioning. However, translating key advances on AAC in non-human primates to tasks in humans has proven difficult in part due to the inherent limitations in existing human tasks in isolating relevant neural substrates of behavior. Here, we present, and validate, a novel task in humans (N= 38) of both sexes, derived from work in non-human primates utilizing primary reinforcers (shock/juice), and in doing so identify neural features specific to conflict, implementing a computational model of task behavior. We found that neural patterns of activation within the parietal, frontal, temporal and cingulate regions were associated with conflict-specific avoidance behavior. Importantly, a number of these regions were associated with trait anxiety, implicating a potential link between these neural regions and anxiety-driven avoidance behavior. This task platform may help advance both behavioral and biological research examining the neural patterning underlying approach-avoidance behavior in humans, providing an empirically oriented framework with which to translate between non-human primate and human work.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Rolle, Camarin Ellen |
|---|---|
| Degree supervisor | Gross, James J, (Professor of psychology) |
| Thesis advisor | Gross, James J, (Professor of psychology) |
| Thesis advisor | Etkin, Amit, 1976- |
| Thesis advisor | Parker, Karen J |
| Thesis advisor | Poldrack, Russell A |
| Degree committee member | Etkin, Amit, 1976- |
| Degree committee member | Parker, Karen J |
| Degree committee member | Poldrack, Russell A |
| Associated with | Stanford University, Neurosciences Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Camarin E. Rolle. |
|---|---|
| Note | Submitted to the Neurosciences Program. |
| Thesis | Thesis Ph.D. Stanford University 2020. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Camarin Ellen Rolle
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...