Molecular mechanisms of membrane fusion at the synapse
Abstract/Contents
- Abstract
- Membrane fusion is a fundamental biophysical process that facilitates synaptic transmission in both the pre- and postsynaptic terminals. Neurotransmitters are released from the presynaptic terminal via synaptic vesicle (SV) fusion with the presynaptic plasma membrane, while postsynaptically, neurotransmitter receptors are inserted via fusion of trafficking vesicles with the postsynaptic membrane. While the key molecules involved in SV fusion, including neuronal SNARES, the calcium sensors synaptotagmins, Munc13, Munc18, complexin, NSF, SNAPs, and many other synaptic proteins have been identified and atomic-resolution structures of some of their complexes determined, much is yet unknown about the architecture of the synaptic proteins in their native environment at the SV docking site. Recently some of the SV fusion proteins have also been found to be important for the insertion of the ionotropic, glutamatergic AMPA receptors (AMPARs) via AMPAR trafficking vesicle (ATV) fusion. However, at present, understanding of the regulation of AMPAR insertion is much more limited compared to SV fusion. In this this, I investigate the mechanisms of membrane fusion both pre- and postsynaptically.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Peters, John Jacob |
|---|---|
| Degree supervisor | Brünger, Axel T |
| Thesis advisor | Brünger, Axel T |
| Thesis advisor | Chen, Lu, (Professor of neurosurgery) |
| Thesis advisor | Ding, Jun (Jun B.) |
| Thesis advisor | Malenka, Robert C |
| Degree committee member | Chen, Lu, (Professor of neurosurgery) |
| Degree committee member | Ding, Jun (Jun B.) |
| Degree committee member | Malenka, Robert C |
| Associated with | Stanford University, Neurosciences Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | John Jacob Peters. |
|---|---|
| Note | Submitted to the Neurosciences Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/vm071cx2792 |
Access conditions
- Copyright
- © 2021 by John Jacob Peters
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