Improving outcomes for Trastuzumab-resistant HER2+ breast cancer using combination treatment with anti-CD47 mAb
Abstract/Contents
- Abstract
- Trastuzumab is a targeted anti-cancer monoclonal antibody that binds the HER2 molecule on HER2-overexpressing breast cancers. Trastuzumab is effective in a neoadjuvant setting when combined with chemotherapy for HER2+ breast cancers that are caught and treated early. However, the majority of patients with advanced HER2+ disease display Trastuzumab resistance: nearly 70% do not respond to initial treatment, and the remaining 30% initially respond yet acquire resistance within one year of treatment. Can anything be done to help patients who develop Trastuzumab resistance? Our lab has previously shown that blockade of CD47, an innate immune checkpoint molecule that cancer cells use to evade programmed cell removal works well in combination with targeted anti-cancer monoclonal antibodies via an Fc-receptor-mediated phagocytosis mechanism. I hypothesize that Trastuzumab may still achieve clinical efficacy in Trastuzumab-resistant HER2+ cancers when used in combination with monoclonal antibodies against CD47.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Upton, Rosalynd Denise |
|---|---|
| Degree supervisor | Weissman, Irving L |
| Thesis advisor | Weissman, Irving L |
| Thesis advisor | Attardi, Laura |
| Thesis advisor | Pegram, Mark |
| Thesis advisor | Shizuru, Judith Anne |
| Degree committee member | Attardi, Laura |
| Degree committee member | Pegram, Mark |
| Degree committee member | Shizuru, Judith Anne |
| Associated with | Stanford University, Cancer Biology Program. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Rosalynd D. Upton. |
|---|---|
| Note | Submitted to the Cancer Biology Program. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Rosalynd Denise Upton
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