Engineered-protein based hydrogels for drug delivery and tissue engineering
Abstract/Contents
- Abstract
- This thesis focuses on studying the structure and properties of engineered elastin-like protein (ELP) based hydrogels, and developing strategies to control the material structure and property for different applications in drug delivery and tissue engineering. Rational control of hydrogel 'bead-string' microstructure was demonstrated to achieve the codelivery and sequential release of hydrophilic and hydrophobic drugs; optical transparency of ELP gels was significantly improved by designing hybrid hydrogels for 3D cell encapsulation; adaptable hydrogel was developed for the use as injectable carriers for both stem cell transplantation and long-term gene therapy; hybrid hydrogels with decoupled matrix parameters were utilized to study the cell-matrix interactions and tissue formation. The achievements presented in this work provide insights for the design of novel biomimetic matrices.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2017 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Wang, Huiyuan |
|---|---|
| Associated with | Stanford University, Department of Materials Science and Engineering. |
| Primary advisor | Heilshorn, Sarah |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Melosh, Nicholas A |
| Thesis advisor | Yang, Fan, (Bioengineering researcher and teacher) |
| Advisor | Melosh, Nicholas A |
| Advisor | Yang, Fan, (Bioengineering researcher and teacher) |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Huiyuan Wang. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2017. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2017 by Huiyuan Wang
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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