Candidate and proteomic approaches to study non-histone lysine methylation
Abstract/Contents
- Abstract
- Lysine methylation is a chemical modification that occurs naturally in proteins. This post-translational modification is small and preserves the charge on the lysine sidechain, making relatively little chemical difference. However, misregulation of lysine methylation can cause a host of human cancers, developmental disorders, and other diseases. The most prominent example of lysine methylation occurs within histone proteins, but it can also occur on non-histone proteins. The proteomic extent of methylation and the diversity of processes it might regulate were previously unclear. The work presented here focuses on identifying the cellular "methylome" and understanding methylation signaling pathways within cells. I also examine the substrate repertoire of the methyltransferase SETMAR and identify the spliceosome component snRNP70 as a novel SETMAR substrate.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2014 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Moore, Kaitlyn Ella |
|---|---|
| Associated with | Stanford University, Department of Chemical and Systems Biology. |
| Primary advisor | Gozani, Or Pinchas |
| Thesis advisor | Gozani, Or Pinchas |
| Thesis advisor | Cimprich, Karlene |
| Thesis advisor | Elias, Joshua |
| Thesis advisor | Straight, Aaron, 1966- |
| Advisor | Cimprich, Karlene |
| Advisor | Elias, Joshua |
| Advisor | Straight, Aaron, 1966- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Kaitlyn Ella Moore. |
|---|---|
| Note | Submitted to the Department of Chemical and Systems Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Kaitlyn Ella Moore
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