A study of select covalent and non-covalent post-translational modifications and their biological consequences
Abstract/Contents
- Abstract
- Post-translational modifications (PTMs) occur on many proteins, and generally exist to change the behavior of the proteins upon which they are found. These modifications can be added or removed by certain classes of enzymes, called "writers" and "erasers" respectively, and their activity can lead to vastly different biological consequences. Still another class of proteins called "readers" are capable of specifically recognizing and binding to proteins that bear certain PTMs, adding another layer of regulation to many different cellular processes. Herein, we expand on the knowledge regarding both "reader" and "writer" proteins, showing evidence for specific interaction between acyl molecules and HEAT- and ARM-repeat containing proteins, as well as demonstrating RPL12 as the physiological substrate of the methyltransferase SETD4 and the role this methylation event plays in regulating mRNA translation elongation.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Coan, John Phillip |
|---|---|
| Degree supervisor | Chua, Katrin Faye |
| Degree supervisor | Gozani, Or Pinchas |
| Thesis advisor | Chua, Katrin Faye |
| Thesis advisor | Gozani, Or Pinchas |
| Thesis advisor | Dixon, Scott James, 1977- |
| Thesis advisor | van Rechem, Capucine |
| Degree committee member | Dixon, Scott James, 1977- |
| Degree committee member | van Rechem, Capucine |
| Associated with | Stanford University, Cancer Biology Program |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | John P. Coan. |
|---|---|
| Note | Submitted to the Cancer Biology Program. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/vc528ch8489 |
Access conditions
- Copyright
- © 2021 by John Phillip Coan
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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