Engineering biomimetic models of human brain development
Abstract/Contents
- Abstract
- Human brain development is the product of spatiotemporally conserved signaling between cells and their microenvironment. Human pluripotent stem cells (hPSCs) have the potential to recapitulate brain development in vitro as cells, either in two-dimensional monolayers or three-dimensional organoids, are differentiated from neuroepithelial stem cells to mature neural circuits. These hPSC-derived models are guided by our understanding of neurodevelopment yet remain limited by our inability to expose cells to the myriad cell-intrinsic and cell-extrinsic signaling cues present in the neurodevelopmental niche. In this thesis, I explore how biomaterials and biofabrication can be leveraged to engineer hPSC-derived models of human brain development which better incorporate biomimetic spatial and temporal signaling cues. .
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Roth, Julien George |
|---|---|
| Degree supervisor | Heilshorn, Sarah |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Chaudhuri, Ovijit |
| Thesis advisor | Palmer, Theo |
| Thesis advisor | Yang, Fan, (Bioengineering researcher and teacher) |
| Degree committee member | Chaudhuri, Ovijit |
| Degree committee member | Palmer, Theo |
| Degree committee member | Yang, Fan, (Bioengineering researcher and teacher) |
| Associated with | Stanford University, School of Medicine |
| Associated with | Stanford University, Program in Stem Cell Biology and Regenerative Medicine |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Julien George Roth. |
|---|---|
| Note | Submitted to the Program in Stem Cell Biology and Regenerative Medicine. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/vc085jq2053 |
Access conditions
- Copyright
- © 2023 by Julien George Roth
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...