Collective cell migration on viscoelastic substrates
Abstract/Contents
- Abstract
- Cells push and pull on the soft tissues of our bodies in order to move around and to gauge the mechanical properties of their surroundings. These physical interactions influence a wide range of key cellular processes, including collective cell migration. Collective migration is a central feature of development, cancer invasion, wound healing, and tissue homeostasis, and relies on coordination of motion and force generation between individual cells. The complexity of cell-material responses and cell-cell interactions gives rise to the rich spectrum of collective behaviors observed in multicellular living systems. In this dissertation, I focus on understanding the role of substrate viscoelasticity in collective cell migration. Specifically, we use engineered biomaterials (i.e., alginate hydrogels) with tunable viscoelastic properties (i.e., solid-like and fluid-like behavior) to study the expansion of micropatterned epithelial monolayers. A more complete understanding of tissue-substrate interactions and collective cell dynamics will provide insight into new therapeutic strategies, tissue engineering approaches, and interventions to promote health and treat diseases.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2023; ©2023 |
| Publication date | 2023; 2023 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Charbonier, Frank William |
|---|---|
| Degree supervisor | Chaudhuri, Ovijit |
| Thesis advisor | Chaudhuri, Ovijit |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Levenston, Marc |
| Degree committee member | Heilshorn, Sarah |
| Degree committee member | Levenston, Marc |
| Associated with | Stanford University, School of Engineering |
| Associated with | Stanford University, Department of Mechanical Engineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Frank Charbonier. |
|---|---|
| Note | Submitted to the Department of Mechanical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2023. |
| Location | https://purl.stanford.edu/tz748sm0857 |
Access conditions
- Copyright
- © 2023 by Frank William Charbonier
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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