Tissue-mimicking electronics : development of miniaturized, soft, stretchable and developmentally morphing bioelectronics
Abstract/Contents
- Abstract
- Implantable devices, such as the vagus nerve stimulator (VNS) and the implantable cardioverter defibrillator (ICD), have been widely used to treat cardiac and neurological diseases. However, they are made of rigid electronic materials. The significant mechanical mismatch between stiff electronics and soft biological tissues causes negative immunoresponses, tissue damage, and device dislocation. To address those problems, we developed soft and electronically active materials with tissue-like Young's modulus and microfabrication methods for stretchable microelectronics. We demonstrated intimate electrical coupling with neural tissues and localized ultralow-voltage electrical stimulation on the peripheral nerves in vivo. To accommodate organ dynamics, such as the beating of the heart, we fabricated a fully elastic microelectrode array for stable electrophysiological recording without electrode displacement during cardiac contraction-relaxation cycles. Epicardial electrophysiological mapping on a chronic atrial fibrillation porcine model showed excellent signal-to-noise ratio and significantly higher spatial resolution compared with the state-of-the-art cardiac mapping system. Finally, we developed an implantable device that can accommodate rapid tissue growth without negatively influencing normal developmental functions. Current implantable bioelectronic devices mechanically constrain the growing tissue due to their fixed shapes and sizes. For infants, children, and adolescents, once implanted devices are 'outgrown', additional surgeries are usually needed for device removal, followed by replacement. These tedious processes inevitably lead to repeated intervention and elevated complication rates. We addressed this limitation by developing Morphing Electronics (termed MorphE), which are designed and fabricated to suitably adapt to in vivo tissue growth with minimal mechanical constraint. Animal studies showed that the soft and self-adapting MorphE caused no damage to a rat nerve after it had grown to 2.4 times its initial diameter. The stable neural interface allowed chronic electrical stimulation and monitoring without disruption of functional behavior in developing animals. As such, MorphE creates a new avenue for adaptive pediatric electronics medicine.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Liu, Yuxin, (Researcher in bioengineering) |
|---|---|
| Degree supervisor | Bao, Zhenan |
| Thesis advisor | Bao, Zhenan |
| Thesis advisor | Cui, Bianxiao |
| Thesis advisor | George, Paul M. (Paul Matthew) |
| Thesis advisor | Yock, Paul G |
| Degree committee member | Cui, Bianxiao |
| Degree committee member | George, Paul M. (Paul Matthew) |
| Degree committee member | Yock, Paul G |
| Associated with | Stanford University, Department of Bioengineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Yuxin Liu. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Yuxin Liu
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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