Resting networks in primary insomnia

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Abstract/Contents

Abstract: Insomnia is a prevalent and costly disorder of sleep-related distress, yet little is known about its etiology. To better understand the neurobiology underlying insomnia, we examined resting state and directed sleep brain activity in insomniacs and healthy controls using simultaneous blood oxygen level-dependent (BOLD) signal functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Using dual regression analysis of BOLD signal brain networks derived from independent component analysis, we found increased coactivation of the insula in salience networks in insomniacs compared to healthy controls. This increase was accompanied by altered EEG power in insomniacs compared to healthy controls, as well as altered BOLD connectivity signatures of EEG frequency bands. These results suggest that aberrant connectivity of the insula and salience networks contribute to neural dysfunction in insomnia.

Type of resource	text
Form	electronic; electronic resource; remote
Extent	1 online resource.
Publication date	2012
Issuance	monographic
Language	English

Associated with	Chen, Michael Cunyuan
Associated with	Stanford University, Department of Psychology
Primary advisor	Gotlib, Ian H
Thesis advisor	Gotlib, Ian H
Thesis advisor	Knutson, Brian
Thesis advisor	Wagner, Anthony David
Advisor	Knutson, Brian
Advisor	Wagner, Anthony David

Genre	Theses

Statement of responsibility	Michael Cunyuan Chen.
Note	Submitted to the Department of Psychology.
Thesis	Thesis (Ph.D.)--Stanford University, 2012.
Location	electronic resource

License: This work is licensed under a Creative Commons Attribution Non Commercial No Derivatives 3.0 Unported license (CC BY-NC-ND).

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