The regulatory landscape of CAR T cell dysfunction
Abstract/Contents
- Abstract
- Chimeric Antigen Receptor (CAR) T cells have emerged as a promising immunotherapy strategy to target cancer in a subset of patients. T cell exhaustion presents a significant barrier to the progress of CAR T cell therapy development and efficacy. We use a human CAR T cell model system, utilizing the non-exhausting CD19-targeting CD19-28z CAR T cells and the in vitro exhausting GD2-targeting HA-28z CAR T cells, to investigate the genetic interactions and regulation underlying CAR T cell exhaustion and dysfunction. We nominate regulatory transcription factors and enhancer loci that control the expression of exhaustion-associated and -promoting genes and perturb these regulatory networks to modulate the exhaustion phenotype and prevent T cells from exhibiting the hallmarks of exhaustion.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Gennert, David George |
|---|---|
| Degree supervisor | Chang, Howard Y. (Howard Yuan-Hao), 1972- |
| Thesis advisor | Chang, Howard Y. (Howard Yuan-Hao), 1972- |
| Thesis advisor | Bassik, Michael |
| Thesis advisor | Greenleaf, William James |
| Thesis advisor | Mackall, Crystal |
| Degree committee member | Bassik, Michael |
| Degree committee member | Greenleaf, William James |
| Degree committee member | Mackall, Crystal |
| Associated with | Stanford University, Department of Genetics |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | David George Gennert. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/tv531yz5755 |
Access conditions
- Copyright
- © 2021 by David George Gennert
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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