Exploring the temporal dynamics of host energetics and metabolism during infection
Abstract/Contents
- Abstract
- Hosts that recover from infection, resilient hosts, pass through three overlapping phases during an infection cycle. In the first phase, the pathogen grows. The host subsequently mounts an immune response and presents clinical symptoms of disease. Ultimately, the resilient host resolves the infection through recovery and repair mechanisms. Scientific studies to date have focused primarily on the identification and understanding of immunological mechanisms and associated pathology, but considerably less time has been spent studying recovery and repair. By shifting our focus to these later events, we stand to learn new things about disease and may identify therapies that improve health during infection and/or speed recovery time. One approach to identifying and testing these mechanisms is to deeply characterize the temporal dynamics of an infection system. Here, we focus our efforts on the study of host energy and metabolism during infection with Plasmodium chabaudi AJ, a murine malarial parasite. As little is known about the energetics of recovery, Chapter 1 reviews literature focusing on the energy and metabolic requirements of immunity. In Chapter 2, we use respirometry cages to characterize an infection cycle with high temporal resolution. To assess the impact of energy in the system, we test glycolytic treatments that alter survival. In Chapter 3, we use a metabolomic approach to monitor changes in host metabolism throughout an infection cycle, and investigate the importance of anti-inflammatory pathways. Chapter 4 synthesizes the results from Chapters 2 and 3, offering new perspectives and opportunities for future research.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2017 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Cumnock, Katherine |
|---|---|
| Associated with | Stanford University, Department of Microbiology and Immunology. |
| Primary advisor | Schneider, David (David Samuel) |
| Thesis advisor | Schneider, David (David Samuel) |
| Thesis advisor | Covert, Markus |
| Thesis advisor | Idoyaga, Juliana |
| Thesis advisor | Relman, David A |
| Advisor | Covert, Markus |
| Advisor | Idoyaga, Juliana |
| Advisor | Relman, David A |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Katherine Cumnock. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2017. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2017 by Katherine Cumnock
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...