Local and global variation in the human gut microbiome
Abstract/Contents
- Abstract
- We increasingly appreciate the role of microbes that live in our gut, collectively referred to as the gut microbiome, in modulating human health and disease. However, translating findings to the clinic has presented challenges, as many studies of the microbiome in health and disease are associational and therefore difficult to translate to meaningful therapies. This thesis focuses on using high-throughput whole-genome sequencing of our gut microbes and computational genomic tools to understand host-microbe dynamics on the strain-specific level, identify opportunities for concrete clinical interventions, investigate the efficacy of existing interventions, and turn our attention to populations who have not been comprehensively studied to establish a baseline for further inquiry toward the microbiome in health and disease. The work herein contributes to our understanding of the microbiome as an influencer of disease outcome and both suggests and informs future microbiome-targeted therapies.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Tamburini, Fiona Blair |
|---|---|
| Degree supervisor | Bhatt, Ami (Ami Siddharth) |
| Thesis advisor | Bhatt, Ami (Ami Siddharth) |
| Thesis advisor | Fire, Andrew Zachary |
| Thesis advisor | Sherlock, Gavin |
| Thesis advisor | Winslow, Monte |
| Degree committee member | Fire, Andrew Zachary |
| Degree committee member | Sherlock, Gavin |
| Degree committee member | Winslow, Monte |
| Associated with | Stanford University, Department of Genetics. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Fiona B. Tamburini. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Fiona Blair Tamburini
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...