Engineering designer biomaterials from topologically diverse polyacrylamide derivatives
Abstract/Contents
- Abstract
- The translational pharmaceutical landscape is rapidly changing and demands new polymers for both drug stability and delivery. Polyacrylamide derivatives have demonstrated a lack of immunogenicity, water solubility, chemical stability, and are both commercially available and inexpensive, making them attractive candidates for translational use. Moreover, polyacrylamides with the chemical, size, and topological control needed for translation can be synthesized via reverse addition fragmentation transfer (RAFT) polymerization, a scalable, robust, and coming-off-patent polymerization technique. This research in this dissertation highlights the promise of polyacrylamide derivatives, synthesized via RAFT, as translational biomaterials. The first portion of this dissertation will describe new developments in insulin formulation technology. I propose the use of polyacrylamide amphiphilic carrier/dopant copolymers (AC/DC) as novel excipients to occupy the air-water interface I will cover the synthesis of a library of AC/DC excipients, the proposed mechanism of action, and formulation work to generate both the (1) fastest acting, stable, injectable insulin formulation and (2) a commercial cold chain resilient insulin formulation. The second portion of the dissertation will describe a new adjuvant platform for subunit vaccines enabled by a hyperbranched polyacrylamide derivative. I will (1) highlight a universal scaling behavior uncovered during the synthesis of these materials, (2) a processing step to generate low-dispersity hyperbranched polymers, and (3) the implementation of adjuvant-conjugated hyperbranched polymers as adjuvants for vaccines. In summary, in this dissertation I will explain how novel polyacrylamide derivative biomaterials can be used to address the need of rapidly changing pharmaceutical landscape.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Mann, Joseph Louis |
|---|---|
| Degree supervisor | Appel, Eric (Eric Andrew) |
| Thesis advisor | Appel, Eric (Eric Andrew) |
| Thesis advisor | Heilshorn, Sarah |
| Thesis advisor | Waymouth, Robert M |
| Degree committee member | Heilshorn, Sarah |
| Degree committee member | Waymouth, Robert M |
| Associated with | Stanford University, Department of Materials Science and Engineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Joseph Louis Mann. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/tq379bg0231 |
Access conditions
- Copyright
- © 2021 by Joseph Louis Mann
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
Also listed in
Loading usage metrics...