mSWI/SNF (BAF) and Topoisomerase II alpha synergize in the regulation of chromatin accessibility, cancer, and neurologic disease
Abstract/Contents
- Abstract
- Mammalian BAF (also known as mSWI/SNF) ATP-dependent chromatin remodeling complexes modulate chromatin and nucleosome structure to regulate chromatin processes such as transcription and DNA replication. Recent sequencing studies have implicated BAF complexes in a variety of human diseases, including a wide variety of neurodevelopmental syndromes and up to 20% of cancers. We have demonstrated that these complexes promote normal cell cycling by facilitating the activity and recruitment of Topoisomerase II [alpha] (TOP2A). We have also shown that BAF complexes mediate chromatin accessibility primarily at distal regulatory regions. Finally, we provide evidence that BAF complexes, along with Topoisomerase II [beta], regulate depolarization-activated ASD-related gene networks. These data illuminate the molecular mechanisms of BAF complexes in both normal and disease settings.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2014 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Miller, Erik Lehman |
|---|---|
| Associated with | Stanford University, Department of Genetics. |
| Primary advisor | Crabtree, Gerald R |
| Thesis advisor | Crabtree, Gerald R |
| Thesis advisor | Baker, Julie, (Professor of genetics) |
| Thesis advisor | Sidow, Arend |
| Thesis advisor | Snyder, Michael, Ph. D |
| Advisor | Baker, Julie, (Professor of genetics) |
| Advisor | Sidow, Arend |
| Advisor | Snyder, Michael, Ph. D |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Erik Lehman Miller. |
|---|---|
| Note | Submitted to the Department of Genetics. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Erik Miller
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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