Investigation of advanced clinical PET system designs
Abstract/Contents
- Abstract
- Positron emission tomography (PET) is a functional radionuclide imaging modality commonly used for managing diseases such as cancer. High-resolution, high-sensitivity, quantitative PET imaging could open up potential new uses in early stage cancer management such as guiding biopsy or surgical resection. Locoregional PET systems with reconfigurable field-of-views (FOV) can further increase the sensitivity and resolution for a specific organ of interest. We will start this thesis by introducing the physics and basic detector designs of PET systems. It will then discuss design and performance of whole-body and locoregional PET system designs that are being investigated in the field. Then, the thesis will describe in detail a 1 mm resolution clinical locoregional PET scanner that is being constructed at Stanford. The design choices and electronics of this system will be discussed, and then system calibrations and performance test results will be shown. Finally, we will discuss additional data correction algorithms specific to this system, such as randoms correction and limited angle tomography image artifact correction algorithms. The results presented in this thesis show that the prototype subsystem of the 1 mm resolution clinical locoregional PET system can achieve spatial resolution of 0.73 mm at the center of the FOV, energy resolution of 11.34%, and coincident timing resolution (CTR) of 13.92 ns. The unique 3D position sensitive scintillation (3D-PSS) detectors used in the system allows for intercrystal scatter positioning algorithms that can be used to improve contrast-to-noise ratio (CNR) by 8.4%, or reduce the patient dose by 12% while maintaining the same image quality. This thesis may be useful for readers that are interested in the physics, electronics, and image quality of high-resolution PET scanners with small scintillation crystal elements. Interesting topics include investigations of detector signal multiplexing across a system, limited angle tomography effects in the reconstructed image, and ICS positioning in a system with multiplexed detectors.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2018; ©2018 |
| Publication date | 2018; 2018 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Hsu, Fan-Chung |
|---|---|
| Degree supervisor | Levin, Craig |
| Thesis advisor | Levin, Craig |
| Thesis advisor | Horowitz, Mark (Mark Alan) |
| Thesis advisor | Nishimura, Dwight George |
| Degree committee member | Horowitz, Mark (Mark Alan) |
| Degree committee member | Nishimura, Dwight George |
| Associated with | Stanford University, Department of Electrical Engineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | David F. C. Hsu. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2018. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2018 by Fan-Chung Hsu
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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