Synthetic glycopolypeptides to study human health
Abstract/Contents
- Abstract
- The field of glycobiology defies the central dogma. Unlike many other post-translational modifications, glycosylation of proteins and the structures of glycan trees are not genetically templated. Consequently, many of the traditional biochemical approaches to studying structure and function are not amenable to studying the structure and function of glycans. Thus, glycobiologists have developed and employed a host of tools to study and manipulate the structure and function of glycans. Chemical biologists have been key to this endeavor, providing numerous metabolic, enzymatic, genetic, and synthetic tools specifically suited to this purpose. Herein, we first review some of these tools, providing a brief historical overview, as well as some recent additions that of which the new chemical glycobiologist should be aware. Then, we describe the applications of a new generation of synthetic glycopolypeptides towards studying receptor-glycan interactions in immunity and, in some cases, bringing these materials towards the clinic through translational research. We leverage glycans to modulate inflammation, in the context of inducing inflammation for immunoncology therapies or inhibiting inflammation in hyperinflammatory conditions.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Delaveris, Corleone Steven |
|---|---|
| Degree supervisor | Bertozzi, Carolyn R, 1966- |
| Thesis advisor | Bertozzi, Carolyn R, 1966- |
| Thesis advisor | Cegelski, Lynette |
| Thesis advisor | Khosla, Chaitan, 1964- |
| Degree committee member | Cegelski, Lynette |
| Degree committee member | Khosla, Chaitan, 1964- |
| Associated with | Stanford University, Department of Chemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Corleone S. Delaveris. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2020. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Corleone Steven Delaveris
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