The signal in the noise : developing tools to extract meaning from biological variation
Abstract/Contents
- Abstract
- Mammalian cells contain a multitude of dynamic structures, from those of force-generating cytoskeletal fibers to the networks of ATP-producing mitochondria. While the structure and dynamics of these systems have been made visible by advances in microscopy, the quantification of useful metrics from these images still requires careful and tailored analysis. Here, I present my work developing statistical tools and analysis pipelines in order to elucidate biological properties and mechanism in three studies: (1) the accurate measurement of cytoskeletal actin velocity distributions, (2) the characterization of mitochondria network topology, and (3) the development of quantitative tools to describe focal adhesion ultrastructure. Taken together, these studies illustrate both the rich biological data which can be extracted from microscopy experiments and the development of quantitative tools which may be useful in the characterization of other cellular structures and processes.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Miller, Cayla Marie |
|---|---|
| Degree supervisor | Dunn, Alexander |
| Thesis advisor | Dunn, Alexander |
| Thesis advisor | Boettiger, Alistair |
| Thesis advisor | Sattely, Elizabeth |
| Degree committee member | Boettiger, Alistair |
| Degree committee member | Sattely, Elizabeth |
| Associated with | Stanford University, Department of Chemical Engineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Cayla M. Miller. |
|---|---|
| Note | Submitted to the Department of Chemical Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/tk562jm0314 |
Access conditions
- Copyright
- © 2021 by Cayla Marie Miller
- License
- This work is licensed under a Creative Commons Attribution Non Commercial No Derivatives 3.0 Unported license (CC BY-NC-ND).
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