Robust variation of the infant gut microbiome around the world
Abstract/Contents
- Abstract
- In the first two years of life, the human gastrointestinal tract goes from a blank slate to a diverse ecosystem of trillions of microorganisms. Throughout infancy, assembly of this microbial ecosystem plays important roles in many aspects of host health, from immune development to metabolism and the central nervous system. Features of lifestyle industrialization, such as hygiene, are linked with a distinct gut microbiota and "missing" indigineous bacteria, whose absence are linked to the onset of chronic inflammatory disease. Relatively little is known about the global variation of the infant microbiome and how lifestyle shapes distinct microbial assemblies. Limitations in our knowledge are due to a lack of deep sequencing data characterizing infants from traditional lifestyles and a paucity of analyses across large cohorts of geographically diverse infants. An introduction to the infant gut microbiota and the key studies that I built my thesis upon are discussed in Chapter 1. The work in Chapter 2 fills gaps in metagenomic reference databases by assembling and curating genomes from gut microbiota of Hadza, a group of modern day hunter-gatherers in Tanzania. In Chapter 3, I use this new database and curate a selection of 2,582 infant samples from around the world to report statistically robust associations between the infant gut microbiota with age and lifestyle. In Chapter 4, databases built and methods established in previous chapters are applied to identify features that associate with healthy infant gut microbiota outcomes in a cohort of infants from an ongoing nutritional intervention trial to treat malnutrition in Pakistan. Finally, Chapter 5 summarises the findings of this study in a proposed model of lifestyle-dependent infant gut microbiota and concludes with a statement of future directions.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Dahan, Dylan |
|---|---|
| Degree supervisor | Sonnenburg, Justin, 1973- |
| Thesis advisor | Sonnenburg, Justin, 1973- |
| Thesis advisor | Holmes, Susan |
| Thesis advisor | Huang, Kerwyn Casey, 1979- |
| Thesis advisor | Relman, David A |
| Degree committee member | Holmes, Susan |
| Degree committee member | Huang, Kerwyn Casey, 1979- |
| Degree committee member | Relman, David A |
| Associated with | Stanford University, Department of Microbiology and Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Dylan Dahan. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/tj834mw6777 |
Access conditions
- Copyright
- © 2021 by Dylan Dahan
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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